Pathology Associates Of Lexington, P.A.
Pathology Associates Of Lexington, P.A.
Pathology Associates Of Lexington, P.A.
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Pancreatic pathology & labs:

  • tumor pathology: *** Stanford's surg. path. CRITERIA.
  • other surgical conditions:
  • medical diseases: such as autoimmune pancreatitis.
Pancreas Auto-Antibodies.
These autoantibodies are of potential importance in working up cases of hypoglycemia and possible cases of autoimmune pancreatitis. 

Hypoglycemic workup: Islet auto-antibodies are said to be able to be detected early in development of type 1 diabetes and are considered to be markers of autoimmune beta cell destruction.  They are said to predict progressive beta cell destruction and ultimately beta cell failure.  The autoantibodies most commonly measured for this workup include islet cell antibodies (ICA), insulin autoantibodies (IAA), glutamic acid decarboxylase antibodies (GADA or GAD65), and protein tyrosine phosphatase-like protein antibodies (insulinoma-associated protein; IA2-ab) antibodies.  The presence of high levels of two or more of these antibodies is strongly predictive of type I diabetes mellitus. 

Autoimmune pancreatitis workup: Typical laboratory findings include increased levels of serum pancreatic enzymes (amylase, lipase, elastase), hypergammaglobulinemia, and the presence of autoantibodies (including ANA, anti-lactoferrin (ALF), anti-carbonic anhydrase II (ACA II), anti-elastase, anti-carboxypeptidase, and anti-alpha-fodrin (this marker may also be involved in Sjogren's syndrome) and anti-mitochondrial antibodies (as in primary biliary cirrhosis, but rarely found in autoimmune pancreatitis). 

References:

  1. Endotext.org website; http://www.endotext.org/protocols/protocols5/protocols5.htm

  2. Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas, Chapter 30, Page 683.

 

(posted 18 August 2004; latest addition 7 February 2009)

 
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