Pathology Associates Of Lexington, P.A.
Pathology Associates Of Lexington, P.A.
Pathology Associates Of Lexington, P.A.
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        Female Lower Genital Tract Neoplasms
      
Uterine Cervix, Vagina, and Vulva:

The following lesions may become more difficult to assess if incidentally found in a post supracervical hysterectomy cervicectomy (trachelectomy...L14-33 was benign)

  • Benign issues:
    1. eosinophilic myometritis or myometropathy.
    2. eosinophilic endocervicitis: an allergenic reaction to some lumenal antigen? [L12-9786].
  • Tumors of the Cervix
    1. Squamous Lesions:
      • Squamous Papilloma 
      • Condyloma Acuminatum
      • Squamous Metaplasia 
      • Transitional Metaplasia 
      • Squamous Atypia
        1. incomplete Atrophy: ccytoplasm shrinkage further than degree of nuclear shrinkage & gives histology & cytology impression of dysplasia but is not (L12-5401). 
        2. Squamous Intraepithelial Lesions, HPV/etc. 
      • Squamous Cell Carcinoma 
      • Microinvasive Carcinoma
      • Invasive Squamous Cell Carcinoma
      • Verrucous Carcinoma 
      • Warty (Condylomatous) Carcinoma 
      • Papillary Squamous (Transitional) Cell Carcinoma 
      • Lymphoepithelial-Like Carcinoma 
    2. Glandular Lesions:
      • Endocervical Polyp
      • Tunnel clusters
      • Metaplasias:
        1. tubal: diffuse ciliation of what otherwise looks like AIS at low power [LMC-04-9684] and has a low Ki67 rate.
      • Müllerian Papilloma
      • Glandular Aytpia
      • Atypical Hyperplasia (Glandular Dysplasia) 
      • Adenocarcinoma In Situ 
      • Mucinous and Endometrioid Adenocarcinoma 
      • Clear Cell Carcinoma 
      • Minimal Deviation Adenocarcinoma 
      • Well-Differentiated (Papillary) Villoglandular Adenocarcinoma 
      • Serous Adenocarcinoma [LMC-02-3386 incidental in hysterect. in 33 y/o]
      • Mesonephric Adenocarcinoma 
    3. Other Epithelial Tumors:
      • Adenosquamous Carcinoma
      • Glassy Cell Carcinoma 
      • Adenoid Cystic Carcinoma
      • Adenoid Basal Carcinoma
      • Carcinoid Tumor (Adenocarcinoma with Features of Carcinoid Tumor) 
      • Small Cell Carcinoma 
      • Undifferentiated Carcinoma 
    4. Mesenchymal Tumors:
      • Leiomyoma 
      • Other Benign Mesenchymal Tumors
      • Stromal decidual change or pseudo-decidual reaction (deciduosis): in pregnant patient unless PROVEN not pregnant (? patient on progestational agents, including NuvaRing [S-06-15285 found 3 months later to be pregnant]).  
      • Leiomyosarcoma 
      • Endocervical Stromal Sarcoma 
      • Sarcoma Botryoides (Embryonal Rhabdomyosarcoma) 
      • Alveolar Soft-Part Sarcoma 
      • Osteosarcoma 
      • Other Malignant Mesenchymal Tumors 
    5. Mixed Epithelial and Mesenchymal (biphasic) Tumors:
      • Papillary Adenofibroma
      • Adenosarcoma 
      • Malignant Mixed Mesodermal Tumor 
      • Wilms Tumor 
    6. Miscellaneous Tumors:
      • Melanocytic Nevus 
      • Blue Nevus 
      • Malignant Melanoma 
      • Lymphoma and Leukemia 
      • Tumors of Germ Cell Type
    7. Secondary Tumors 
    8. Tumor-Like Lesions:
      • Mesodermal Stromal Polyp (pseudosarcoma botryoides) 
      • Microglandular Hyperplasia 
      • Mesonephric Remnants 
      • Mesonephric Hyperplasia 
      • Arias-Stella Reaction 
      • Endometriosis 
      • Cysts 
      • Decidual Nodule 
      • Placental-Site Nodule
      • Amputation (Traumatic) Neuroma 
      • Postoperative Spindle Cell Nodule 
      • Intestinal Metaplasia 
      • Tubal Metaplasia
      • Epidermal Metaplasia 
      • Glial Polyp 
      • Tunnel Clusters 
      • Lymphoma-Like Lesion (Pseudolymphoma) 
  • Tumors of the uterine corpus
  • Tumors of the Vagina 
    1. Squamous Lesions:
      • Squamous Papilloma 
      • Condyloma Acuminatum
      • Transitional Metaplasia
      • Squamous Atypia 
      • Squamous Intraepithelial Lesions
      • Squamous Cell Carcinoma 
      • Verrucous Carcinoma 
      • Warty (Condylomatous) Carcinoma 
    2. Glandular Lesions:
      • Adenosis 
      • Atypical Adenosis 
      • Müllerian Papilloma 
      • Endometrioid, Endocervical, and Intestinal-Type Adenocarcinomas 
      • Clear Cell Adenocarcinoma 
      • Mesonephric Carcinoma 
    3. Other Epithelial Tumors:
      • Adenosquamous Carcinoma
      • Adenoid Basal Carcinoma
      • Adenoid Cystic Carcinoma
      • Carcinoid Tumor and Small Cell Carcinoma
      • Undifferentiated Carcinoma 
    4. Mesenchymal Tumors:
      • Leiomyoma
      • Rhabdomyoma
      • Other Benign Mesenchymal Tumors
      • Leiomyosarcoma
      • Sarcoma Botryoides (Embryonal Rhabdomyosarcoma) 
      • Endometrioid Stromal Sarcoma
      • Other Malignant Mesenchymal Tumors
    5.   Mixed Epithelial and Mesenchymal (biphasic) Tumors:
      • Mixed Tumor
      • Mixed Tumor Resembling Synovial Sarcoma
      • Adenosarcoma 
      • Malignant Mixed Mesodermal Tumor 
    6. Miscellaneous Tumors:
      • Melanocytic Nevus
      • Blue Nevus 
      • Malignant Melanoma 
      • Yolk Sac Tumor
      • Mature Cystic Teratoma 
      • Adenomatoid Tumor 
      • Villous Adenoma 
      • Malignant Lymphoma and Other Lymphohistiocytic Lesions 
    7. Secondary Tumors 
    8. Tumor-Like Lesions:
      • Vaginal Polyp (Mesodermal Stromal Polyp)
      • Postoperative Spindle Cell Nodule
      • Vault Granulation Tissue
      • Prolapsed Fallopian Tube 
      • Endometriosis
      • Decidua 
      • Cysts 
      • Lymphoma-Like Lesion 
  • Tumors of the Vulva & external urethra:
    1. Squamous Lesions:
      • Squamous (Vestibular) Papilloma 
      • Fibroepithelial Polyp 
      • Condyloma Acuminatum 
      • Seborrheic Keratosis 
      • Keratoacanthoma 
      • Squamous Intraepithelial Lesions 
      • Squamous Cell Carcinoma 
      • Superficially Invasive Squamous Cell Carcinoma 
      • Invasive Squamous Cell Carcinoma 
      • Basaloid Carcinoma 
      • Verrucous Carcinoma 
      • Warty (Condylomatous) Carcinoma 
      • Basal Cell Carcinoma 
    2. Glandular Lesions:
      • Papillary Hidradenoma (Hidradenoma Papilliferum) 
      • Nodular (Clear Cell) Hidradenoma 
      • Syringoma 
      • Trichoepithelioma 
      • Trichilemmoma 
      • Adenoma of Minor Vestibular Glands
      • Paget Disease 
      • Bartholin Gland Tumors 
      • Breast Carcinoma and Other Tumors Arising in Ectopic Mammary Tissue 
      • Carcinomas of Sweat Gland Origin 
      • Other Adenocarcinomas 
    3. Benign Mesenchymal Tumors:
      • Lipoma/Fibrolipoma 
      • Hemangioma 
      • Angiokeratoma 
      • Pyogenic Granuloma 
      • Lymphangioma 
      • Fibroma 
      • Leiomyoma 
      • Granular Cell Tumor 
      • Neurofibroma 
      • Schwannoma (Neurilemmoma) 
      • Glomus Tumor 
      • Fibrous Histiocytoma 
      • Rhabdomyoma 
    4. Malignant Mesenchymal Tumors:
      • Embryonal Rhabdomyosarcoma (Sarcoma Botryoides) 
      • Aggressive Angiomyxoma 
      • Leiomyosarcoma 
      • Dermatofibrosarcoma Protuberans 
      • Malignant Fibrous Histiocytoma 
      • Epithelioid Sarcoma
      • Malignant Rhabdoid Tumor 
      • Malignant Schwannoma 
      • Angiosarcoma
      • Kaposi Sarcoma 
      • Hemangiopericytoma 
      • Liposarcoma 
      • Alveolar Soft-Part Sarcoma 
    5. Miscellaneous Tumors:
      • Benign Melanocytic Tumors 
      • Malignant Melanoma 
      • Malignant Lymphoma
      • Tumors of Germ Cell Type 
      • Neuroectodermal Tumors
    6. Secondary Tumors 
    7. Tumor-Like Lesions:
      • urethral caruncle: usually in postmenopausal women & is small, reactive, [polypoid mucosa, inflamed & with dilated vessels & can be a mucosal varix, even thrombosed [L12-14795].
      • Pseudoepitheliomatous Hyperplasia 
      • Endometriosis and Decidua 
      • Langerhans Cell Histiocytosis (Histiocytosis X Including Eosinophilic Granuloma)
      • Benign Xanthogranuloma
      • Verruciform Xanthoma
      • Desmoid Tumor (Extra-abdominal Fibromatosis, Aggressive Fibromatosis) 
      • Sclerosing Lipogranuloma
      • Nodular Fasciitis 
      • Nevus Lipomatosis Superficialis 
      • Crohn Disease 
      • Cysts 
    8. Other Epithelial Disorders of Skin and Mucosa:
      • Lichen Sclerosus (Formerly Lichen Sclerosus et Atrophicus) 
      • Squamous Cell Hyperplasia (Formerly Hyperplastic Dystrophy)
      • other dermatological conditions

References:

  1. AFIP web site, this topic, Kurman RJ, Norris HJ, Wilkinson EJ, as of 10/2001
 
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