Pathology Associates Of Lexington, P.A.
Pathology Associates Of Lexington, P.A.
Pathology Associates Of Lexington, P.A.
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         Lactate Dehydrogenase test, blood
      
Lactate Dehydrogenase, Serum
This is one of the serum enzymes commonly present in general laboratory chemistry panels or profiles.

Causes of DECREASED Values/Levels
  • medications (analytical artifact vs. real)
  • aging
  • hemodialysis

Causes of Increased Values/Levels
  • hemolysis within a mishandled or too old specimen
  • hemolytic anemia
  • situations of "ineffective erythropoiesis" (premature cell death of bone marrow red blood cell precursors (unless combined with other nutritional deficiencies, especially iron deficiency):
    • megaloblastic anemia (B12 or Folate deficiency)
    • myelodysplastic syndromes (MDS)
  • muscle injury
  • hypothyroidism
  • myocardial infarction
  • pulmonary infarction (released from RBC's)
  • SARS with blood lymphopenia
  • liver injury: ischemic factors elevate LDH, as with heart failure, other vascular ischemic etiologies, and acetaminophen.
  • renal infarction
  • chronic alcoholism
  • mononucleosis
  • leukemia or lymphoma: the "international index" [Shipp criteria ] for lymphoma staging utilizes LDH (normal vs. elevated) as one of the criteria
  • excessive cellular destruction situations  (i.e. chemotherapy or extensive malignancies)
  • acute pancreatitis
  • collagen diseases
  • strenuous exercise activity
  • medications (analytical artifact vs. real)

Test Synonyms

Other names for this exact or approximate agent are:   

  • LDH, serum
  • Lactic Dehydrogenase, serum
 
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