Pathology Associates Of Lexington, P.A.
Pathology Associates Of Lexington, P.A.
Pathology Associates Of Lexington, P.A.
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        Anti-Liver Kidney Microsomal Antibody Test, Blood
      

Anti-LKM is an autoantibody which has been said to be found in some liver diseases...generally accepted as a marker of autoimmune hepatitis (AIH) type II. The Ab is directed against LKM1. Classical testing is by IFA on rat liver & kidney. That same substrate can react with similar positive pattern in presence of antibodies to liver cytosol type 1 and to antimitochondrial antibodies.

Associations with undetectable Ab:

  • normalcy

Associations with elevated levels:

  • autoimmune hepatitis (AIH) type II

  • chronic hepatitis C associated AIH

  • about 6% of hepatitis C cases (hepatitis C often has other associated antibodies which, too, may not be clinically significant)

REFERENCES:

1. LKM-Positive AIH in the Western US: A Case Series, A. J. Gastroent. 95(11):3238-3241, 2000.

(posted 2000; latest addition 14 March 2005)
 
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